25. T.R. Knight was the comedian behind the scenes.
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With all of that downtime, it’s a great place to get to know each other and it turns out that Knight had “the best sense of humor on set,” according to Heigl.
26. Isaiah works with real doctors to train for his part.
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He says that he still goes to “open heart surgeries whenever I can or brain surgeries whenever I can. That just helps me keep my edge.”